A quantum machine may solve some complex problems that are intractable for even the most powerful classical computers. By exploiting quantum superposition and entanglement phenomena, quantum algorithms can achieve from polynomial to exponential speed up when compared to their best classical counterparts. A quantum computer will be a part of a heterogeneous, multi-core computer in which a classical processor will interact with several accelerators such as FPGAs, GPUs and also a quantum co-processor. Figure 1 shows the different layers of the quantum computer system stack [1]. Building such a quantum system requires contributions from different fields such as physics, electronics, computer science and computer engineering for addressing the following challenges: i) build scalable quantum chips integrating qubits with long coherence times and high-fidelity operations, ii) develop classical control electronics at possibly cryogenic temperatures and iii) create the microarchitecture as well as the software for quantum computation. © 2018 IEEE.